可穿戴设备可以检测出先于症状和炎症性类风湿性关节炎爆发并与之相关的生理变化
Pragya Sharma1, Matteo Danieletto1,2, Jessica K Whang3
1Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Scientific reports
|November 29, 2025
概括
可穿戴设备可以检测出预测类风湿性关节炎 (RA) 爆发的生理变化. 来自Apple Watch和Fitbit等设备的心率和步骤数据可能有助于监测RA疾病活动.
科学领域:
- 类风湿病学 类风湿病学
- 生物医学工程 生物医学工程
- 数字健康数字健康
背景情况:
- 类风湿性关节炎 (RA) 涉及生理变化.
- 监测RA疾病活动和预测爆发对于患者管理至关重要.
研究的目的:
- 调查可穿戴设备的生理指标是否可以识别和先于类风湿性关节炎 (RA) 爆发.
- 评估可穿戴技术对RA疾病监测和爆发预测的潜力.
主要方法:
- 收集了RA患者使用可穿戴设备 (Apple Watch,Fitbit,Oura Ring) 的生理数据 (心率,心率变化,步骤).
- 利用线性混合效应模型和Cosinor混合效应模型来分析生理指标和RA爆发/缓解期之间的关联.
- 采用混合效应逻辑回归来评估发作前的生理变化.
主要成果:
- 与缓解相比,在症状性RA期间观察到较低的平均步骤和更高的夜间心率 (HR).
- 每日HR,白天HR,夜间HR和休息心率 (RHR) 的升高与炎症性RA爆发相比缓解有关.
- 心率变化 (HRV) 的循环特征区分了炎症/症状爆发和缓解.
- 在所有测量的生理指标中,在炎症和症状性RA爆发前四周内检测到显著的变化.
结论:
- 来自可穿戴设备的生理数据显示,对监测类风湿性关节炎 (RA) 疾病活动有前途.
- 可穿戴技术可能提供一种非侵入性方法来预测RA爆发,从而能够及时进行干预.
相关概念视频
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
448
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
448
01:20Rheumatic Heart Disease IV: Nursing Management
251
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
251
01:23Rheumatic Heart Disease I: Introduction
408
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
408
01:11Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K
01:21Rheumatic Heart Disease III: Medical Management
267
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
267
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
326
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
326