疫苗接种后视神经炎的治疗:全球SARS-CoV-2疫苗接种工作的含义
Yan Ning Neo1, Lidia Martinez-Alvarez2,3, Indran Davagnanam1
1Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London, EC1V 2PD, UK.
概括
接种SARS-CoV-2疫苗后的视神经炎是可以治疗的,视力恢复良好. 早期的皮质类固醇治疗可以保护视网膜层,强调在与疫苗相关的视神经炎中需要迅速干预.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
背景情况:
- 在COVID-19大流行之前,疫苗接种后视觉神经炎 (ON) 被认为是罕见的.
- 追溯研究发现ON是接种疫苗后与视力相关的严重并发症.
- 鉴于全球免疫努力,了解疫苗相关的ON至关重要.
研究的目的:
- 为了研究SARS-CoV-2疫苗接种后的视神经炎的特征和结果.
- 评估早期治疗疫苗接种后的疗效.
- 将疫苗接种后的ON与大流行前的发病率研究进行比较.
主要方法:
- 由国际ON联盟 (ICON) 进行的一年期前性多中心后续研究.
- 使用预先规定的协议和国际共识诊断标准进行ON诊断.
- 评估治疗开始速度,视力敏度和光学连贯性断层扫描 (OCT) 度量.
主要成果:
- 来自15个国家的73人接受了ON后SARS-CoV-2疫苗接种.
- 与历史数据相比,接种后的ON呈现出更多的双边病例和较早的发病.
- 早期的皮质类固醇治疗显著保留了视网膜神经纤维和质细胞层.
结论:
- 接种疫苗后的ON显示了良好的功能性视觉恢复.
- 快速的皮质类固醇治疗提供神经保护,并保护视网膜结构.
- 长期管理策略应考虑自身抗体的存在.
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