前列腺中的雌激素调节是良性前列腺增生症男性的种族差异的基础
Teresa T Liu1,2, Laura E Pascal3,4, Emily A Ricke2
1Wegmans School of Pharmacy, St. John Fisher University, Rochester, NY, USA.
The Journal of pathology
|November 30, 2025
概括
雌激素受体 (ER) 和类固醇代谢基因表达的种族差异与老年男性的良性前列腺激增症 (BPH) 和下泌尿道症状 (LUTS) 有关. 了解这些途径可能会导致针对LUTS/BPH的向治疗.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
- 病理学 病理学 病理学
背景情况:
- 下尿道症状 (LUTS) 影响全球超过2.10亿男性,通常与良性前列腺增生症 (BPH) 相关.
- 雌激素受体α (ERα) 途径与BPH进展有关,而雌激素受体β (ERβ) 途径被认为是保护性的.
- 与欧洲裔美国人 (EA) 男人相比,非洲裔美国人 (AA) 男人表现出更高的LUTS/BPH发病率和较差的治疗结果.
研究的目的:
- 调查正常和LUTS/BPH前列腺组织中ER表达和类固醇代谢的种族差异.
- 评估ER信号通路在不同种族群体LUT/BPH发育中的作用.
主要方法:
- 利用多重,多光谱成像来检查外围区域 (PZ) 和过渡区 (TZ) 前列腺组织中的ER表达.
- 评估了与正常与LUTS/BPH前列腺样本中的ERs和与ERβ信号相关的类固醇代谢基因的变化.
主要成果:
- 在正常的AA和EA前列腺之间确定了不同的类固醇代谢基因表达特征,在LUTS/BPH中进一步改变.
- 在EA样本中,ERα对LUTS/BPH的贡献更为明显.
- AA前列腺样本显示ER和雌激素代谢基因的表达增加,而对原体沉积没有显著差异.
结论:
- 在良性前列腺中存在类固醇激素信号通路的种族差异.
- 这些发现突出了开发针对特定ER途径的精密疗法的潜力,用于LUTS/BPH管理.
- 对这些种族差异的进一步研究可以改善老年男性患有LUTS/BPH的治疗策略.
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