在5岁之前疾病发作的患者中,乳病的症状
Melanie P Parziale1, Julia R Kleinhenz2, Taylor Abbey3
1Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, Illinois, USA.
Journal of pediatric gastroenterology and nutrition
|November 30, 2025
概括
幼儿的乳病 (CeD) 根据症状发病的年龄呈现不同. 早期发病 (24个月前) 与更严重的症状和住院有关,而晚期发病显示更多的腹痛和更少的肠外症状.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 自免疫性疾病 自免疫性疾病
- 临床研究 临床研究
背景情况:
- 性疾病 (CeD) 是一种自身免疫性疾病,由摄入质引发.
- 虽然CeD呈现已知在老年儿童和成年人中,但在学龄前儿童中不太了解.
- 症状可以从胃肠道问题到偏头痛和皮疹等非胃肠道症状.
研究的目的:
- 描述在5岁之前出现症状的患者中CeD的临床表现和血清学值.
- 为了比较CeD在24个月前出现症状的儿童中的表现与24个月后的表现.
主要方法:
- 在一个小儿科 CeD 机构进行了回顾性图表审查.
- 确定了82名被诊断为CeD的儿童,症状在5岁之前出现.
主要成果:
- 在24个月前出现症状的儿童有更高的症状负担,包括吐,情绪变化,体重增加不佳和线性生长不佳.
- 这一较年轻的子组也更有可能在诊断后不久就入院.
- 在24个月后出现症状的儿童更有可能经历腹痛和更少的肠外症状.
- 无论症状发病年龄,都没有观察到诊断时间的显著差异.
结论:
- 这项研究强调了CeD在幼儿年龄患者的多样化肠外表现.
- 它还表明,在这个年龄组的诊断时间,住院的发生率增加.
- 这些发现有助于理解年轻儿科患者中CeD.
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