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Updated: Jan 6, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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基于三碳烯的PROTACs降解了SARS-CoV-2的Mpro蛋白酶

Liuruiqi Luo1, Yuxiang Lu1, He Meng1

  • 1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, IGCME, School of Chemistry, Sun Yat-Sen University, Guangzhou, China.

Chemistry (Weinheim an der Bergstrasse, Germany)
|November 30, 2025
PubMed
概括

研究人员开发了metallo-PROTACs,这是一种使用金属复合物用于向蛋白质降解的新方法. 这一策略增强了细胞吸收和功效,克服了传统PROTACs的主要局限性.

关键词:
这就是PROTAC.在SARS-CoV-2主要蛋白酶中.金属复合体金属复合体蛋白质降解 蛋白质降解

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