探索2型糖尿病中的生物标志物与通过高通量蛋白质组学识别的正常血糖:系统性审查和元分析
Julia García-Currás1,2, Raquel Pérez-Lois3,4, Guillermo L Taboada1
1Universidade da Coruña (UDC), Grupo Arquitectura de Computadores, Centro de Investigación en Tecnologías de la Información y las Comunicaciones (CITIC), Elviña, A Coruña 15071, Spain.
Journal of proteome research
|November 30, 2025
概括
本综述通过分析27项研究,确定了2型糖尿病 (T2D) 的关键蛋白质生物标志物. 三个一致的生物标志物 (ORM1,HP,AZGP1) 显示出对T2D诊断和管理的希望.
科学领域:
- 蛋白质组学和代谢组学
- 生物标志物发现发现
- 系统生物学 系统生物学
背景情况:
- 2型糖尿病 (T2D) 是一个重要的全球健康问题,具有复杂的代谢基础.
- 蛋白质组学的进步允许早期识别蛋白质生物标记物和T2D中的代谢转变.
- 系统审查和元分析对于合成各种蛋白质组数据至关重要.
研究的目的:
- 对2型糖尿病的蛋白质组学研究进行系统的审查和元分析.
- 识别和验证与T2D相关的蛋白质生物标志物.
- 通过蛋白质分析,探索涉及T2D病原体的功能途径.
主要方法:
- 系统的文献搜索产生了2,422条记录,其中包括27项研究.
- 使用 QUADOMICS 的方法质量评估,专注于报告标准.
- 85种重复性蛋白质的定性合成和生物标志物候选者的基于奥米克的元分析.
主要成果:
- 方法报告在样本处理方面表现强,但在临床因素和验证方面表现弱.
- 确定了85种参与免疫反应,脂质代谢和凝血的复发性蛋白质.
- 确定了七个有前途的T2D蛋白质生物标志物,其中ORM1,HP和AZGP1在研究中显示出一致的结果.
结论:
- 蛋白质组分析揭示了对T2D至关重要的相互连接的途径.
- ORM1,HP和AZGP1代表了2型糖尿病的一致和有前途的生物标志物.
- 有一个交互式工具,metaMarkersT2D,可用于进一步的数据探索.
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