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由SARS-CoV-2引起的胎盘感染:探索其他进入途径

Carolina Lumi Tanaka Dino¹, Barbara Maria Cavalli¹, Carolline Konzen Klein²

¹Center for Health Sciences, Postgraduate Program of Obstetrics, Gynecology, and Women's Health, Federal University of Paraná - UFPR, Curitiba, Brazil.

Tissue barriers

|November 30, 2025

概括

这项研究调查了SARS-CoV-2的胎盘进入途径,发现NRP-1和Clathrin表达减少,并在COVID-19胎盘中增加了Cathepsin L. 这些变化表明,除了正规的ACE2/TMPRSS2通路之外,还有其他病毒进入机制.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
产科产科产科产科产科

背景情况:

SARS-CoV-2 胎盘检测引发了人们对病毒进入机制的担忧.
正规的ACE2/TMPRSS2通路可能不是胎盘感染的唯一途径.

研究的目的:

为了评估SARS-CoV-2胎盘进入分子 (ADAM17,Cathepsin L,Clathrin,ACE-2,Furin,NRP-1,TMPRSS2) 的免疫组织化学表达.
用RT-qPCR检测胎盘组织中的病毒RNA.
为了调查潜在的替代SARS-CoV-2胎盘进入途径.

主要方法:

免疫组织化学用于分析75个COVID-19和19控制胎盘样本中的蛋白质表达.
通过RT-qPCR检测到帕拉芬嵌入的胎盘组织中的SARS-CoV-2RNA.
统计分析比较了COVID-19和对照组之间的表达模式.

主要成果:

在COVID-19组 (p < 0.001) 的决定体中观察到显著减少的NRP-1表达,包括RT-qPCR阳性样本 (p = 0.001).
在COVID-19组的体样本 (p = 0.05) 和RT-qPCR阳性样本 (p = 0.013) 中,clathrin表达显著降低.
在COVID-19组的胎盘里 (p < 0.001) 和RT-qPCR阳性样本 (p = 0.005) 中,甲素L表达显著增加.

结论:

研究结果表明,SARS-CoV-2可能利用辅助和/或内细胞通道进入胎盘.
改变NRP-1,Clathrin和Cathepsin L的表达可能在SARS-CoV-2的胎盘相互作用中发挥作用.
需要进一步的研究,以了解这些胎盘变化的影响在母体SARS-CoV-2感染.

关键词:

细胞内存症是指细胞内存症.孕产妇和胎儿之间的接口.胎盘胎盘胎盘胎盘病毒入口病毒入口.病毒感染病毒感染

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