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相关概念视频

The Physiology of Taste01:24

The Physiology of Taste

7.0K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
7.0K
Taste Buds and Receptors01:20

Taste Buds and Receptors

4.5K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
4.5K
Gustation01:43

Gustation

51.7K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
51.7K

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相关实验视频

Updated: Jan 6, 2026

µTongue: A Microfluidics-Based Functional Imaging Platform for the Tongue In Vivo
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µTongue: A Microfluidics-Based Functional Imaging Platform for the Tongue In Vivo

Published on: April 22, 2021

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相对成像平台将味觉细胞功能与分子身份联系起来.

Sungho Lee1,2, Minjae Kim1,2, Gha Yeon Park1,2

  • 1School of Biological Sciences, Seoul National University, Seoul, 08826, Republic of Korea.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|November 30, 2025
PubMed
概括

研究人员开发了一个新的成像平台,将味觉细胞功能与基因表达联系起来. 这可以更深入地了解味觉细胞如何处理信息,并为味觉感知做出贡献.

关键词:
相关成像成像是相关的成像.在活体中成像成像一个单细胞分析.空间转录组空间转录组味道 味道 味道 味道 味道

更多相关视频

Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds
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Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds

Published on: February 11, 2021

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In vivo Calcium Imaging of Mouse Geniculate Ganglion Neuron Responses to Taste Stimuli
07:27

In vivo Calcium Imaging of Mouse Geniculate Ganglion Neuron Responses to Taste Stimuli

Published on: February 11, 2021

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相关实验视频

Last Updated: Jan 6, 2026

µTongue: A Microfluidics-Based Functional Imaging Platform for the Tongue In Vivo
07:53

µTongue: A Microfluidics-Based Functional Imaging Platform for the Tongue In Vivo

Published on: April 22, 2021

4.8K
Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds
07:40

Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds

Published on: February 11, 2021

3.9K
In vivo Calcium Imaging of Mouse Geniculate Ganglion Neuron Responses to Taste Stimuli
07:27

In vivo Calcium Imaging of Mouse Geniculate Ganglion Neuron Responses to Taste Stimuli

Published on: February 11, 2021

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科学领域:

  • 神经科学是一个神经科学.
  • 细胞生物学 细胞生物学
  • 感官生物学 感官生物学

背景情况:

  • 了解味觉细胞生理学需要整合基因表达和功能数据.
  • 目前的方法缺乏对味觉细胞的相关单细胞分析,这阻碍了亚型的识别.
  • 这种差距限制了对味觉细胞亚型及其作用的全面理解.

研究的目的:

  • 开发一种关联成像平台,将味觉细胞功能与分子身份联系起来.
  • 从相同的味觉细胞同时获取功能成像和分子数据.
  • 推进对味觉细胞亚型和味觉信息处理的研究.

主要方法:

  • 为完整的味蕾开发了一个相关成像平台.
  • 利用近红外标记 (NIRB) 来实现活体和固定组织之间的空间对应.
  • 集成功能成像与现场杂交或免疫光.

主要成果:

  • 证明酸味细胞在转录和转化水平上表达碳酸无水酶IV (CA4).
  • 发现甜味/乌玛米反应是由所有Tas1R亚型共同表达的味觉细胞调解的.
  • 通过共同表达,展示了口味品质的组合编码.

结论:

  • 开发的相关平台成功将味觉细胞功能与分子身份联系起来.
  • 酸味细胞是通过CA4表达分子定义的.
  • 味觉受体的共同表达是复杂的味觉感知的基础,促进了味觉信息处理的理解.