血清阴性腹腔疾病的诊断评估
Andrew Ford1, Claire Jansson-Knodell2, Alberto Rubio-Tapia2
1MetroHealth Medical Center, MetroHealth Dr Cleveland, OH, USA.
血清阴性腹病 (SNCeD) 缺乏传统的标志物,使诊断复杂化. 调查肠道IgA抗TG2沉积的新测试和HLA-DQ四相酶测试显示,可以更快地识别SNCeD.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 病 (CeD) 是一种自身免疫性疾病,通常通过血清学和十二指肠活检诊断.
- 血清阴性腹病 (SNCeD) 没有这些血清学标志物,这给诊断带来了挑战.
- 目前的SNCeD诊断包括排除其他疾病和确认HLA-DQ2/DQ8基因型,然后进行无质饮食 (GFD),这需要时间.
研究的目的:
- 探索SNCeD的新型诊断方法.
- 为了确定SNCeD的更简洁,更有效的诊断方法.
- 评估新兴的测试,以评估它们在SNCeD诊断中的潜在应用.
主要方法:
- 审查正在进行的CeD诊断的研究和调查.
- 测试的评估,包括肠道IgA抗TG2沉积物.
- 对SNCeD潜在的HLA-DQ四聚合物测定,微RNA,互白素-2和流细胞计的评估.
主要成果:
- 一些有前途的诊断标志物正在为CeD进行调查.
- 这些新兴的测试也可能适用于诊断SNCeD.
- 肠道IgA抗TG2沉积物和HLA-DQ四聚体测定是研究的关键领域之一.
结论:
- 现有的SNCeD诊断途径是繁的.
- 新的血清和细胞测定为改善和更快的SNCeD诊断提供了潜力.
- 对这些新型试验的进一步研究对于SNCeD的临床应用至关重要.
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