一个关于季节性流感病例死亡风险的系统审查
Johnny A N Filipe1, Carlos K H Wong2, Edwin van Leeuwen3
1Department of Infectious Disease Epidemiology and Dynamics, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.
Vaccine
|November 30, 2025
概括
使用诊断的症状病例死亡风险 (sCFR) 估计季节性流感的严重程度显示出广泛的全球差异. 更标准化的数据收集对于准确的流感负担和疫苗接种影响评估至关重要.
科学领域:
- 流行病学 流行病学
- 传染病研究 传染病研究
- 公共卫生监督 公共卫生监督
背景情况:
- 病例死亡风险 (CFR) 是流感严重程度和负担估计的一个关键指标.
- 实验室确认的病例死亡风险 (cCFR) 受医疗保健系统因素的影响.
- 诊断症状病例死亡风险 (sCFR) 在不同卫生系统中提供了一个潜在的更一致的衡量标准.
研究的目的:
- 系统地审查有关季节性流感sCFR的现有研究.
- 评估不同地点和季节的sCFR估计的变化.
- 确定导致sCFR观察到变化的因素.
主要方法:
- 对报告sCFR或其估计数据的研究的系统文献综述.
- 包括10项研究,提供40个特定位置和季节的sCFR点估计.
- 与地理和社会经济因素相关的sCFR变化的分析.
主要成果:
- 观察到广泛的sCFR估计值 (0.3908每10万例).
- 在不同的地理区域中,sCFR存在显著的差异.
- 一个地理区域内的季节性变化可能比地理差异更为明显.
结论:
- 在sCFR估计的实质性的异质性需要进一步调查.
- 社会经济因素不能完全解释观察到的sCFR的地理差异.
- 标准化协议和增加数据收集对于全球可靠的sCFR估计至关重要.
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