在未接种疫苗的日本青少年中,HPV疫苗相关症状的发生率:来自VENUS研究数据库的描述性研究
Yurika Kawazoe1, Tomohiro Katsuta2, Toshihiro Tanaka3
1Clinical Research Center, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki-shi, Nagasaki 852-8501, Japan.
Vaccine
|November 30, 2025
概括
在未接种疫苗的日本青少年中观察到不同的症状 (DS),患病率为0.15%. 皮肤问题,睡眠障碍,头痛和月经不规则是最常见的,为HPV疫苗安全性讨论提供了关键数据.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 日本的人类乳头瘤病毒 (HPV) 疫苗接种率在暂停9年后恢复缓慢.
- 了解未接种疫苗的人群中不同症状 (DS) 的患病率对于疫苗安全性评估至关重要.
研究的目的:
- 在未接种疫苗的日本青少年中确定各种症状 (DS) 的流行率.
- 提供独立于HPV疫苗接种的症状发生的客观数据.
主要方法:
- 一项基于人口的描述性研究,使用来自四个日本市的医疗保险和免疫数据.
- 包括2017年4月至2022年3月期间10-19岁未接种疫苗的个人.
- 定义了使用ICD-10代码对27种症状的DS,不包括可识别的潜在疾病的病例.
主要成果:
- 在未接种疫苗的青少年中,DS的总体患病率为0.15%,女性的患病率略高.
- 最常见的DS包括皮肤问题 (10-14岁的男性),睡眠障碍 (15-19岁的女性),头痛 (10-14岁的女性) 和月经不规则 (15-19岁的女性).
- 在各市镇或在COVID-19大流行期间,没有观察到DS患病率的显著变化.
结论:
- 在没有接种HPV疫苗的日本青少年中存在DS的客观证据.
- 这些发现可以为关于HPV疫苗安全性的讨论提供信息,并有助于改善日本的疫苗接种.
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