通过结构启用发现了碳酸酸前药物,作为潜在的向谷氨酸酶C的强效抑制剂

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Hanyu Sun1, Shize Li1, Chengxia Mao2

  • 1State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China; Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China.

Bioorganic chemistry
|November 30, 2025
PubMed
概括

研究人员开发了针对谷氨酸酶C (GAC),癌症代谢中的关键酶的新型前期药物. 产药16通过抑制GAC和阻断谷氨胺代谢,表现出强大的抗癌活性.

关键词:
艾洛斯特抑制剂 艾洛斯特抑制剂这是一种抗瘤药物.在 GAC 中,GAC 是一个有价值的组织.一个药物产品.

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