高温暴露通过破坏肠-大脑轴损害认知功能:来自人类和老鼠研究的证据
Lai-Bao Zhuo1, Jie Zhao2, Weidong Wu1
1School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Ecotoxicology and environmental safety
|November 30, 2025
概括
高温 (HT) 暴露会损害人类和老鼠的认知功能. 这种下降与肠-大脑轴的破坏有关,包括炎症和减少有益细菌.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 高温 (HT) 暴露对潜在的健康影响越来越令人担忧.
- 人们越来越认识到肠-大脑轴是影响认知功能的关键途径.
- 了解环境因素与神经健康之间的相互作用至关重要.
研究的目的:
- 研究高温 (HT) 暴露对认知功能的影响.
- 探索肠-大脑轴作为HT诱导的认知变化中介途径的作用.
- 评估神经炎症,肠道屏障功能和肠道微生物群的改变.
主要方法:
- 通过ACE-R评估人类认知功能;根据职业生涯持续时间定义的HT暴露.
- 鼠标模型暴露在不同温度 (25-40°C) 的认知测试 (MWM).
- 分析包括神经退行标志物,炎症分析,肠道微生物群概况 (16S rRNA) 和SCFA代谢学.
主要成果:
- 在人类和老鼠中,HT暴露显著降低了认知得分 (ACE-R,MWM) 和记忆力.
- 在大鼠中观察到海马神经元损伤,神经炎症和质激活.
- HT 破坏了肠道平衡,减少了SCFA 生产细菌和SCFA,导致肠道炎症和屏障功能障碍.
结论:
- 高温暴露会对认知功能产生负面影响.
- 肠-大脑轴,涉及肠道微生物群和炎症,是调解这些效应的关键途径.
- 研究结果提供了关于HT相关认知衰退背后的生物学机制的见解.
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