相关实验视频

Updated: Jul 25, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

基于绵羊尾巴脂肪的纳米结构脂质载体的制备和表征

Linze Liu¹, Hangqi Ren¹, Yilan Wu¹

¹College of Food Science and Engineering, Inner Mongolia Agricultural University, 306 Zhaowuda Road, Hohhot, Inner Mongolia 010018, China; China-Mongolia Biomacromolecule Application "Belt and Road" Joint Laboratory, Hohhot, Inner Mongolia 010018, China; Engineering Research Center of Comprehensive Utilization of Livestock By-products of Inner Mongolia Autonomous Region, Hohhot 010018, Inner Mongolia, China.

|November 30, 2025

概括

绵羊尾巴脂肪形成有效的纳米结构脂质载体 (NLC) 供应氨酸. 通过Tween 80稳定和更高的凝固温度实现了最佳生物可访问性,这突显了NLC结晶控制的重要性.

科学领域:

脂质纳米粒子技术的技术
生物活性化合物输送系统
食品科学与技术食品科学与技术

背景情况:

纳米结构脂质载体 (NLC) 是生物活性化合物的先进输送系统.
绵羊尾巴脂肪提供了一个独特的脂质矩阵,由于其混合的高和低点脂质.
了解NLC特性对于有效的生物活性化合物封装和释放至关重要.

研究的目的:

用羊尾脂作为脂质矩阵来准备和描述NLC.
研究固化温度和表面活性剂对NLC特性的影响.
评估开发的NLC的素 (Qc) 传递效率和生物可访问性.

主要方法:

使用羊尾脂和各种Tweens (20,40,60,80) 的NLC制备.
物理化学分析包括粒子大小和泽塔潜力.
结晶行为,消化特性和封装效率评估.
在不同的条件下确定奎尔的生物可访问性.

主要成果:

在60天内,NLC颗粒大小在251-285nm之间.
在80个稳定NLC (T80-NLC) 之间,在25°C固化,表现出最大的Qc封装 (82.9%) 和生物可访问性 (42.8%).
较低的固化温度 (4°C) 将T80-NLC的生物可访问性降低到19.3%,这是由于中断的界面结构.

结论:

绵羊尾巴脂肪是NLC配方的可行的脂质矩阵.
表面活性剂的选择和固化温度显著影响NLC结晶,稳定性和Qc生物可访问性.
优化的NLC配方,如在25°C凝固的T80-NLC,增强氨酸的输送和生物可用性.

关键词:

生物可访问性生物可访问性结晶化结晶化结晶化纳米结构脂质载体纳米结构脂质载体羊的尾巴脂肪是羊的尾巴脂肪.在Tween期间,

更多相关视频

Preparation, Purification, and Use of Fatty Acid-containing Liposomes

Preparation, Purification, and Use of Fatty Acid-containing Liposomes

Published on: February 9, 2018

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

相关概念视频

Structure of Lipids

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...

Micelles

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

Formation of Lipopolysaccharides

Formation of Lipopolysaccharides

Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin, triggering...