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Updated: Jan 9, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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在KPC-33中的 conformational动力学和基质选择性:通过多尺度分子动力学模拟揭示了对ceftazidime-avibactam耐药性的分子机制

Zuguo Zhao1, Caihong Ye1, Wei Zhang1

  • 1Department of Microbiology and Immunology of School of Basic Medicine of Guangdong Medical University, Dongguan, Guangdong, China.

Journal of pharmaceutical and biomedical analysis
|November 30, 2025
PubMed
概括

克莱布西拉肺炎卡巴佩内马斯 (KPC) -33是一种KPC-2的变体,可以抵抗ceftazidime-avibactam (CAZ-AVI). 分子动力学揭示D179Y替代改变了酶动力学,有利于CAZ结合和逃避阿维巴克坦抑制.

关键词:
艾维巴克塔姆是一种药物.塞夫塔齐迪姆 (Ceftazidime) 是一种一种克莱布西拉肺炎 (Klebsiella pneumoniae carbapenemase) 是一种新型肺炎菌.分子动力学分子动力学电阻 电阻 电阻 电阻 电阻 电阻

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Enzyme Kinetics01:19

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Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
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