来自Dioscorea polystachya残留物的生物活性蛋白通过抑制TXNIP/NLRP3通路在老鼠中缓解皮胺诱导的勃起功能障碍
Shiting Yu1, Yiwen Zhang1, Jiao Xi1
1Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, China.
International journal of biological macromolecules
|November 30, 2025
概括
研究人员从中国子副产品中分离了DP1蛋白,发现它通过减少氧化应激和炎症来有效治疗勃起功能障碍. 这种蛋白质对男性健康和利用食品工业废物有很大的前景.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 循环经济是一个循环经济.
背景情况:
- 食品工业的副产品提供了宝贵的蛋白质资源.
- 迪奥斯科雷亚多菌 (中国) 的副产品含有生物活性蛋白质.
- 在治疗勃起功能障碍方面,DP1蛋白的潜力尚未被探索.
研究的目的:
- 从中国果残留物中分离和描述DP1蛋白质.
- 调查DP1的生物活动,特别是其在勃起功能障碍中的有效性.
- 阐明DP1影响背后的分子机制.
主要方法:
- 从Dioscorea polystachya残留物中分离和净化蛋白质.
- 对DP1.1的结构和热稳定性的分析.
- 在体内和体外测定使用皮胺诱导勃起功能障碍的老鼠模型.
- 测量氧化 (NO),循环氨酸单酸盐 (cGMP),氧化应激标记物和NLRP3炎症酶激活.
主要成果:
- DP1是一种稳定的单蛋白 (11.751 kDa),具有极好的热稳定性.
- 在大鼠中,DP1的使用改善了勃起功能,增加了勃起率并减少了延迟时间.
- DP1增强了NO和cGMP水平,恢复了内皮功能,抑制了TXNIP线粒体穿,减少了氧化应激,并抑制了NLRP3炎症酶激活.
结论:
- 从中国子副产品中分离出来的DP1蛋白显示出治疗勃起功能障碍的巨大潜力.
- DP1通过减轻氧化应激和NLRP3炎症酶激活来发挥其保护作用.
- 这项研究强调了中国副产品在开发男性生殖健康功能性补充食品方面的价值.
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