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在衰老的巨细胞和肥胖症的单细胞中,cGAS-STING信号受损

Carine Raquel Richter Schmitz¹, Lucas Kich Grun², Bruno Kendi Makiyama³

¹Graduate Program in Biological Sciences: Biochemistry, Federal University at Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Group of Inflammation and Cellular Senescence, Immunobiology Laboratory, School of Health Sciences and Life, Pontifical Catholic University at Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.

Mechanisms of ageing and development

|November 30, 2025

概括

该cGAS-STING通路显示衰老细胞和肥胖个体的细胞功能障碍,表明衰老和肥胖中免疫问题的共享机制. 这会影响免疫防御和炎症.

科学领域:

免疫学免疫学免疫学
细胞衰老细胞衰老
代谢性疾病是一种代谢性疾病.

背景情况:

循环GMP-AMP合成酶 (cGAS) 刺激干扰素基因 (STING) 途径对于先天免疫和无菌炎症至关重要.
这种途径的失调与衰老,肥胖和慢性炎症有关.

研究的目的:

研究cGAS-STING信号通路在衰老的单细胞衍生巨细胞 (MDMs) 和肥胖个体的单细胞中.
探索衰老和肥胖中免疫功能障碍的潜在共享机制.

主要方法:

人类MDMs被差异化和培养以诱导复制性衰老.
从瘦身和肥胖的参与者中分离出单细胞.
评估了衰老标志物 (P16,γH2AX,β-galactosidase),端粒长度,LAMIN B1,细胞化,STING表达和cGAS-STING通路的反应.

主要成果:

衰老的MDMs表现出衰老的标志,减少了STING表达,并损害了cGAS-STING信号传输.
肥胖个体的单细胞显示老化标志物增加,STING表达升高,下游信号受损,细胞因子分泌量减少.

结论:

免疫细胞中功能失调的cGAS-STING信号传递和衰老标记表明一种共同的途径有助于衰老和肥胖的免疫功能障碍.
了解这种途径在免疫细胞中的作用,可以了解与年龄相关的免疫衰退和慢性炎症.

关键词:

衰老的衰老衰老的衰老循环二核酸是循环的二核酸.过度响应过度响应骨髓状细胞是什么? 骨髓状细胞是什么?肥胖问题肥胖问题

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