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来自Ganoderma lucidum发酵的小麦皮中的多糖:净化,结构特征和降脂机制

Yue Sun¹, Cheng Li¹, Le Yan¹

¹Department of Food Science and Engineering, Shandong Agricultural University, Tai'an, PR China; Engineering and Technology Center for Grain Processing in Shandong Province, Tai'an, PR China.

Carbohydrate polymers

|November 30, 2025

概括

来自发酵小麦皮的新型多糖体FPP-1-a有效降低脂质,并对抗代谢障碍. 这种来自小麦的化合物在治疗肥胖和相关疾病方面表现有前途.

科学领域:

生物化学生物化学
食品科学食品科学食品科学
药理学药理学是指药理学的学科.

背景情况:

小麦花皮是多糖的丰富来源.
固态发酵 (SSF) 可以提高多糖含量和生物活性.
光 (Ganoderma lucidum) 以其有益的生物活性化合物而闻名.

研究的目的:

为了净化和表征一种多糖从小麦皮发酵的小麦.
在油酸诱导的HepG2细胞模型中评估净化多糖的降脂效应.
研究其代谢益处的潜在机制.

主要方法:

小麦皮的固体发酵 (SSF) 使用光.
使用分子量测定和单糖分析等技术,对多糖分 (FPP-1-a) 进行净化和结构性表征.
在体外评估对油酸诱导的HepG2细胞的降脂作用.
分析与脂质代谢和细胞信号通路 (例如AMPK) 相关的基因表达.

主要成果:

SSF显著增加了小麦皮中的可溶性托含量.
得到了纯化的多糖分离物,FPP-1-a,其分子量为8.577kDa.
FPP-1-a显著降低了甘油三,总胆固醇和LDL水平,同时增加了HepG2细胞中的HDL水平.
FPP-1-a减轻了氧化应激和炎症,并激活了AMPK通路,调节了脂原和脂解基因表达.

结论:

FPP-1-a是从发酵的小麦骨中提取的多糖,具有强大的降脂和抗代谢障碍的特性.
该研究强调了利用小麦加工副产品开发功能成分的潜力.
FPP-1-a的机制涉及AMPK通路的激活,为肥胖和相关代谢疾病提供了有前途的治疗剂.

关键词:

这种植物叫做Ganoderma lucidum.脂质代谢脂质代谢是一种聚糖类是多糖类的.固态发酵发酵过程中的固态发酵.结构性表征结构性表征

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