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Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
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通过含有OE-MSCs的神经细胞外基质/碳甲基/氧化酸水凝进行增强的脊髓损伤修复

Elham Seidkhani1, Soraya Mehrabi2, Fatemeh Moradi3

  • 1Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Carbohydrate polymers
|November 30, 2025
PubMed
概括

这项研究开发了一种生物活性可注射的水凝,使用神经细胞外基质 (ECM),碳甲基 (CMC) 和氧化藻酸盐 (OA) 结合嗅觉衍生的生体外细胞干细胞 (OE-MSCs) 进行脊髓损伤 (SCI) 修复.

关键词:
碳氧甲基基托桑是一种碳氧甲基基托桑.动态 动态 动态 动态细胞外矩阵是细胞外矩阵.可以注射的水凝.氧化过的阿尔基酸盐.脊髓损伤导致的脊髓损伤

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...