开发和验证一种快速的TEIS-TQMS选方法,用于在非生物样本中识别8种NPS
Bartłomiej Feigel1, Piotr Adamowicz2, Sławomir Wybraniec3
1Institute of Forensic Research, Westerplatte 9, 31 033 Cracow, Poland; Cracow University of Technology, Department of Chemical Technology and Environmental Analytics, Warszawska 24, 31-155 Cracow, Poland.
Science & justice : journal of the Forensic Science Society
|November 30, 2025
概括
法医专家开发了一种快速查新精神活性物质 (NPS) 的方法. 热提取离子源-三极四极并列质谱 (TEIS-TQMS) 技术在一分钟内分析8个NPS,简化了药物分析.
科学领域:
- 法医化学 法医化学
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 新型精神活性物质 (NPS) 的普及率不断增加,对法医分析提出了重大挑战.
- 现有的选方法难以跟上NPS市场的多样性和快速发展.
- 及时分析NPS对于执法和司法程序至关重要.
研究的目的:
- 开发一种快速有效的选方法,用于同时确定多个NPS.
- 为满足法医毒理学更快分析周转时间的需求.
- 为了简化在现实世界中的法医样本中进行NPS分析的样本准备.
主要方法:
- 热提取离子源的应用与三极四极并列质谱学 (TEIS-TQMS) 相结合.
- 对目标NPS的分析,包括大麻素,胺和甲基.
- 根据ANSI/ASB标准进行验证,评估干扰,选择性,矩阵效应和检测极限.
主要成果:
- 成功开发了一种能够在一分钟内分析8个NPS (包括5-MEO-MIPT,3-MMC,alpha-PVP) 的方法.
- 检测极限在0.01至6.47μg/ml之间,矩阵效应在-97%至241%之间.
- 该方法表现出高效率和简化样品制备 (用甲醇进行固体液体提取).
结论:
- TEIS-TQMS在快速选NPS方面取得了重大进展,通常被称为"合法高".
- 开发的方法简化了毒理学评估和专家报告,有利于法医和检察工作流程.
- 这种技术有可能加快涉及NPS分析的刑事诉讼程序.
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