脂质复合指数与中年妇女喘之间的非线性关系:NHANES 2007-2016年间的一项横截面研究
Feng Chen1,2, Wenxiu Xie3, Jiao Yu4
1Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine (900th Hospital), Fuzhou, China.
概括
较高的非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比率 (NHHR) 与中年妇女喘风险增加有关. 这表明,脂质代谢失调可能会影响呼吸系统健康,特别是在受教育程度较低的女性中.
科学领域:
- 心血管健康 心血管健康
- 呼吸系统医学 呼吸系统医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 喘不成比例地影响成年女性,表明疾病负担的性别差异.
- 异常的脂质代谢与喘发病有关,但女性非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比率 (NHHR) 的作用尚不清楚.
研究的目的:
- 调查NHHR与中年女性喘风险之间的关联.
- 探索NHHR对喘风险的非线性关系和潜在值影响.
主要方法:
- 利用了2007-2016年国家健康和营养检查调查 (NHANES) 的数据.
- 在30-65岁的7337名女性队列中使用多变量后勤回归,平滑曲线拟合和子组分析.
主要成果:
- 在多个因素调整后,较高的NHHR独立地与喘风险增加有关 (OR = 1.26).
- 观察到非线性关系,喘风险显著增加,超过大约1.17.7的NHHR值.
- 这种联系在受教育程度较低的女性中更为强烈.
结论:
- 升高的NHHR独立且非线性地与中年女性的喘风险有关.
- 不调节的脂质代谢,由NHHR表示,可能有助于女性喘易感性.
- NHHR可以作为影响女性呼吸系统健康的代谢-炎症相互作用的生物标志物.
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