咖啡因和IBD风险:一个元分析
Xiangying Wu1,2, Jinqin Jiang1,2, Qin Lu1,2
1Department of Rehabilitation, Jingmen Central Hospital, Jingmen, Hubei, China.
Journal of gastroenterology and hepatology
|November 30, 2025
概括
咖啡因摄入量没有显示出与炎症性肠病 (IBD) 风险的总体联系,但区域和人口因素很重要. 咖啡和茶可以降低性结肠炎的风险,而咖啡因可能会增加美国人和青少年的风险.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),包括具有潜在遗传,环境和饮食联系的慢性肠道疾病.
- 以前关于咖啡因摄入量和IBD风险的研究产生了相互矛盾的结果,需要进一步调查.
研究的目的:
- 系统地审查和对现有研究进行元分析,以澄清咖啡因消费与IBD发展风险之间的关联.
- 探索潜在的缓和因素,如地理区域,年龄,咖啡因来源,吸烟状态和教育水平.
主要方法:
- 在多个数据库 (CNKI,VIP,Wanfang,PubMed,Embase,JBI,WOS) 进行了全面的文献搜索,截至2024年5月21日.
- 包括的研究是前性,横截面和病例对照设计,检查咖啡因摄入量和IBD风险.
- 数据提取和质量评估由两位研究人员独立进行,并使用Stata 16.0.0进行元分析.
主要成果:
- 对21项研究 (13,209名参与者) 的元分析发现,咖啡因摄入量与IBD风险之间没有显著的总体关联 (RR=0.84).
- 然而,咖啡因摄入量与美国人的UC风险增加68% (RR=1.68) 以及在18岁以下的个人中增加4.52倍的IBD风险 (RR=4.52).
- 相反,咖啡 (RR=0.43) 和茶 (RR=0.54) 消费与降低UC风险有关,而咖啡因在吸烟者中增加了80%的CD风险 (RR=1.80).
结论:
- 咖啡因对IBD风险的影响是复杂的,受地理位置,年龄,咖啡因来源,吸烟习惯和教育背景的影响.
- 咖啡和茶可以在亚洲和欧洲人群中提供对UC的保护作用.
- 咖啡因消费,特别是在美国人口和青少年中,可能会增加UC风险,强调需要个性化风险评估.
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