由于Globicatella spp.引起的尿路感染. 在患有复杂泌尿病症的儿科患者中
Elena Berardinelli1, Agustina Mancini1, María Elena Venuta1
1Microbiology Department, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.
Revista Argentina de microbiologia
|November 30, 2025
概括
在儿童中,Globicatella尿路感染并不常见,通常与复杂的尿路问题有关. 这项研究突出了它们的特征和抗生素耐药性模式,特别是对 ceftriaxone.
科学领域:
- 微生物学 微生物学
- 儿童传染病 儿童传染病
- 临床泌尿病学 临床泌尿病学
背景情况:
- 格洛比卡特拉菌是导致尿路感染 (UTI) 的格兰氏阳性菌.
- 由于Globicatella引起的尿路感染很少被报告,特别是在儿科患者中.
- 患者经常出现潜在的尿路病变或先天性异常.
研究的目的:
- 描述儿童Globicatella尿道感染的临床特征和抗菌敏感性.
- 为提供关于这种罕见的儿科感染的详细报告.
主要方法:
- 对27种Globicatella spp.阳性尿液和尿路结石培养的回顾性分析.
- 使用质谱法 (Vitek MS),16S rRNA基因测序和生物化学测试识别的分离物.
- 抗微生物敏感性测试,包括对和青素的最小抑制度 (MIC).
主要成果:
- 大多数感染发生在患有复杂泌尿病症的患者中.
- 观察到高的塞夫triaxone (CRO) MICs (MIC50/MIC90: 2-16μg/mL) 的情况.
- 青素 (PEN) 在近一半的分离物中表现出较低的MIC (MIC50/MIC90:0.25-2μg/mL).
结论:
- 格洛比卡特拉菌在儿科尿路感染中代表着潜在的病原体,特别是在具有结构性尿路异常的儿童中.
- 观察到的高抗素耐药性需要在治疗策略中考虑.
- 需要进一步的研究,以了解全球菌感染的全部临床意义和最佳管理.
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