沉默的威胁:与PM2.5相关的男性生殖健康挑战
Yuan Gao1, Jie Wu2, Jinmei Cheng2
1Experimental Animal Center, Nantong University, Nantong, Jiangsu, China.
Archives of toxicology
|November 30, 2025
概括
细颗粒物2.5 (PM$_{2.5}$) 的污染与男性生育能力下降和精液质量低下有关. 暴露会通过氧化应激,荷尔蒙干扰和表观遗传变化影响男性生殖健康,需要采取保护措施.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- 全球生育率正在下降,同时增加了对细颗粒物2.5 (PM$_{2.5}$) 空气污染的暴露.
- PM$_{2.5}$给公共卫生带来了重大挑战,人们对其对男性生殖健康的影响越来越担心.
研究的目的:
- 综合审查PM$_{2.5}$暴露对男性生殖健康的多方面的影响.
- 综合流行病学发现,机制性见解和与PM$_{2.5}$和男性生育相关的潜在缓解策略.
主要方法:
- 对PM$_{2.5}$和男性生殖结果的流行病学研究和实验研究的系统审查.
- 分析生物途径,包括氧化应激,内分泌干扰和表观遗传修饰.
主要成果:
- 在PM$_{2.5}$暴露和男性生殖不良结果之间发现了显著的关联,例如生育能力下降和精液质量受损.
- PM$_{2.5}$通过氧化应激,线粒体功能障碍,内分泌干扰 (合成) 和表观遗传改变产生有害影响.
- 这些分子变化共同损害了精子生成和男性生殖功能.
结论:
- 暴露于PM$_{2.5}$与男性生殖功能障碍和生育能力下降密切相关.
- 迫切需要提高公众意识,并采取有效的保护措施,防止空气污染对男性生育能力的不利影响.
- 对缓解策略的进一步研究是有必要的,以减少与PM$_{2.5}$暴露相关的生殖风险.
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