母亲遗传风险评分对出生体重跨种族身份和祖先的概括性:对前性队列研究的二次分析
Bita Tristani-Firouzi1, Lisa Pappas1, Merry Joseph1
1Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah, USA.
BJOG : an international journal of obstetrics and gynaecology
|November 30, 2025
概括
对出生体重的遗传风险评分 (GRSBW) 是有前途的,但在美国队列中的不同种族和祖先群体中无法概括. 需要进一步的研究,以了解各种人群中对胎儿生长的遗传影响.
科学领域:
- 遗传学 是一个遗传学.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 人口健康 人口健康
背景情况:
- 母亲基因型可能会对胎儿生长评估进行定制.
- 跨不同种族和祖先群体的遗传风险得分的概括性仍然不确定.
- 使用主要是欧洲祖先的数据开发出了出生体重的遗传风险评分 (GRSBW).
研究的目的:
- 评估GRSBW在美国人口中的普遍性.
- 为了测试母亲的GRS和婴儿出生体重之间的关联.
- 评估这种关联在不同自我认同的种族和基因预测的祖先群体中的强度.
主要方法:
- 来自美国八个招聘中心的8147名无孕患者的前性观察队伍的二次分析.
- 使用日志线性建模来测试母亲GRSBW与婴儿出生体重的关联.
- 在自我认同的种族和基因预测的大陆祖先 (GPA) 群体中评估了关联.
主要成果:
- 在整体队列中,GRSBW与出生体重 (p <0.001) 有积极的关联.
- 这种关联在白人和多种族群体中是显著的,但在黑人或亚洲群体中没有.
- 这种关联在欧洲和美国的祖先群体中是显著的,但在非洲,东南亚或未知的祖先群体中没有.
结论:
- GRSBW不能在各种自我描述的种族身份或基因预测的祖先群体中进行概括.
- 强调需要全球代表性的遗传发现队伍.
- 强调需要进一步调查种族,种族和表观遗传因素在胎儿生长中的复杂作用.
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