运动以强度依赖的方式改善肠道微生物代谢物:随机对照试验的综合分析
Dejan Reljic1,2,3, Hans Joachim Hermann1,2,3, Walburga Dieterich1,2,3
1Department of Medicine 1 - Gastroenterology, Pneumology and Endocrinology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Gut microbes
|December 1, 2025
概括
高强度间歇训练显著提升了肠道微生物.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 肠道微生物组研究研究
背景情况:
- 肥胖和代谢综合征 (MetS) 是全球重要的健康问题.
- 肠道微生物组及其代谢物,短链脂肪酸 (SCFA),对于心脏代谢健康至关重要.
- 运动越来越多地被认为是它在调节SCFA产生的作用.
研究的目的:
- 调查低体积高强度 (HIGH-EX) 与中等强度 (MOD-EX) 间歇训练对肥胖的MetS患者SCFA和心脏代谢标志物的影响.
- 为了比较HIGH-EX和MOD-EX对肠道微生物群代谢物和健康结果的影响,两者与抵抗训练相结合.
- 分析来自三项随机对照试验的综合数据,以提供有关运动强度和代谢健康的有力的证据.
主要方法:
- 来自三项随机对照试验的113名患者的综合分析.
- 干预包括12周的HIGH-EX,MOD-EX或对照组 (CON),每组都进行抵抗训练.
- 评估了干预前和后的便SCFA度,心肺健康 (VO2max),肌肉强度,炎症 (hsCRP) 和MetS严重程度 (MetS z-score),并通过血液乳酸监测运动强度.
主要成果:
- 无论是HIGH-EX还是MOD-EX都改善了心肺呼吸能力,肌肉力量,减少了炎症 (hsCRP),并降低了MetS严重程度.
- 只有HIGH-EX显著增加了便中的SCFA总量,包括乙酸盐,酸盐和丁酸盐.
- 训练期间血中乳糖的增加与SCFA的产生有很强的相关性,这表明运动强度和微生物变化之间存在联系.
结论:
- 结合低体积间歇和阻力训练,可以在中度和高强度的运动中改善身体健康和代谢健康.
- 高强度间歇训练特别增强SCFA的产生,可能是通过乳酸介导机制.
- 运动强度是影响运动干预措施肠道代谢益处的关键因素.
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