肺部恶性病的立体性废除性放射治疗后局部衰竭的救援切除:一个回顾性,单中心研究
Eun Chae Kim1, Samina Park1, Eun Ji Hong2
1Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Journal of chest surgery
|December 1, 2025
概括
在立体性除性放射治疗 (SABR) 后的救援肺切除是可行的,并且对于局部衰竭是安全的. 这项研究表明,切除后没有局部复发,这表明在仔细选择患者时的有效性.
科学领域:
- 胸部外科手术 胸部外科手术
- 辐射瘤学 辐射瘤学
- 手术瘤学手术瘤学
背景情况:
- 放射治疗后的救援切除具有重大技术挑战和并发症风险.
- 经过立体性废除性放射治疗 (SABR) 后的救援肺切除后的结果仍然不完全理解.
- 在SABR后局部衰竭需要评估替代治疗策略.
研究的目的:
- 评估救援切除在SABR之后局部复发的可行性和安全性.
- 评估在救援切除后的短期术后结果和中期复发率.
- 为了确定救援切除在SABR后局部故障管理中的有效性.
主要方法:
- 在SABR (2012-2018) 后进行局部复发的救援切除患者的回顾性审查.
- 对患者人口统计,病理,复发时间,手术方法和切除边缘的分析.
- 评估术后并发症,死亡率,住院时间和复发模式.
主要成果:
- 16名患者接受了17次SABR后局部衰竭的救援切除;结直肠癌转移最常见 (71%).
- 视频辅助胸腔镜手术 (VATS) 用于13次手术,在所有情况下都实现了R0切除;8次需要解剖切除.
- 没有30或90天的死亡率;一个患者有需要干预的出血;在中位数为58.1个月的随访期间没有发生局部失败.
结论:
- 挽救切除是SABR后局部衰竭的安全有效的治疗选择.
- 获得完整的 (R0) 切除对于成功的结果至关重要.
- 仔细的患者选择对于优化SABR后的救援肺切除结果至关重要.
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