在现场协调组装纳米药物/样本,用于增强瘤保留和响应释放
Fanqi Liu1, Xindi Li1, Suying Xu1
1State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Angewandte Chemie (International ed. in English)
|December 1, 2025
概括
这项研究引入了一种新的策略,使用瘤微环境 (TME) 响应的纳米平台来增强药物保留和有针对性的输送. 开发的纳米激光剂改善了瘤的成像和治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 改善瘤药物保留和实现瘤微环境 (TME) 响应释放是癌症治疗中的关键挑战.
- 目前的纳米载体在持续释放和在瘤部位内的有效积累方面经常面临限制.
研究的目的:
- 为增强瘤保留和响应性药物释放制定TME刺激的协调组合策略.
- 为多式成像和协同疗法创建一个多功能纳米异能平台.
主要方法:
- 合成的过氧化铜 (CuO2) 纳米颗粒被-化 (Zn-F) 封装.
- 利用CuO2的TME响应性分解来触发Cu-F纳米平台的现场自组装.
- 在体外和体内对光声成像 (PAI),19F磁共振成像 (19F-MRI),光热疗法 (PTT) 和化学动力疗法 (CDT) 的纳米平台进行了评估.
主要成果:
- Cu-F纳米平台在瘤部位表现出增强的保留能力.
- 获得了对TME敏感的PAI,19F-MRI和PTT.
- 催化过氧化转化为CDT的有毒基.
- 激活了cGAS-STING通路,增强了免疫细胞死亡.
结论:
- 在现场协调组装的战略提供了一个有希望的方法,开发TME-响应的nanotheranostics.
- 开发的纳米平台表现出增强的瘤保留和卓越的治疗效果.
- 这一策略有可能通过改善药物输送和治疗疗效来推进癌症治疗.
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