酶可切换的诱导热的聚合物结合物用于协调癌症免疫治疗中的宿主免疫反应
Torsha Ghosh1, Jueun Jeon1, Van Hieu Duong1
1School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Advanced materials (Deerfield Beach, Fla.)
|December 1, 2025
概括
一种新型的聚合物合物EPIC精确地触发癌细胞中的热亡 (编程细胞死亡). 这种方法可以增强抗瘤免疫力,并显示出有效的癌症免疫治疗的前景,从而导致持续的瘤缓解.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 加斯德明-D介导的热死对免疫力至关重要,也是潜在的癌症免疫治疗点.
- 在癌症治疗中,在空间时间上控制热仍然是一个重大挑战.
研究的目的:
- 开发一种新型的聚合物合物 (EPIC),用于精确的,酶激活的癌细胞中激素灭诱导.
- 评估EPIC作为癌症免疫治疗剂的疗效,单独和与抗PD-1疗法结合使用.
主要方法:
- 一种可酶切换的诱导热的聚合物合物 (EPIC) 被设计为通过癌细胞中的Cathepsin B激活.
- EPIC诱导化学发光共振能量转移 (CRET),导致反应性氧物种的产生和溶酶体的破坏.
- 在体外和体外研究评估了EPIC引发热,激活免疫细胞和治疗小鼠瘤的能力.
主要成果:
- EPIC在癌细胞中选择性地触发了热,释放了与损伤相关的分子模式和细胞因子.
- 在携带瘤的小鼠中,EPIC促进了树突细胞成熟和NK细胞活性.
- 与EPIC和抗PD-1抗体的联合治疗显著增强了抗瘤免疫力,导致超过50%的小鼠长期缓解和完全瘤回归.
结论:
- EPIC是用于精确癌症免疫治疗的多功能纳米平台.
- 通过诱导免疫细胞死亡和增强抗瘤免疫反应,EPIC显示出有效的癌症治疗的巨大潜力.
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