相关实验视频
Updated: Jan 9, 2026
07:59
Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
21.0K
移植功能障碍与移植后晚期的CMV感染有关
Angela Zeng1, Katherine Barraclough1,2, Michael Lian1
1Department of Nephrology, Royal Melbourne Hospital, Melbourne, VIC, Australia.
Frontiers in transplantation
|December 1, 2025
概括
移植脏后的晚期细胞巨乳病毒 (CMV) 感染并不常见,但与更糟糕的结果有关. 功能障碍是关键预测因素,这表明有风险的患者有针对性的监测.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 传染性疾病 传染性疾病
背景情况:
- 细胞巨乳病毒 (CMV) 感染是移植后的重大并发症,影响患者的发病率和死亡率.
- 晚期的CMV感染 (移植后≥2年发生) 不太常见,与早期感染相比,潜在的风险因素和结果可能不同.
研究的目的:
- 研究移植患者晚期CMV感染相关的风险因素和临床结果.
- 为了比较没有CMV感染,早期CMV感染 (<2年) 和晚期CMV感染 (≥2年) 的患者之间的特征和结果.
主要方法:
- 在2009年至2019年期间,对接受脏移植的接受者进行了一项单一中心的回顾性研究.
- 患者被分为三个组:没有CMV感染,早期CMV感染和晚期CMV感染.
- 分析了临床数据和结果,并在各组进行了比较.
主要成果:
- 供体阳性/受体阴性 (D+/R-) 血清状态与早期的CMV感染 (66.7%) 有显著的关联,但与晚期感染 (7.1%) 没有关联.
- 在早期CMV感染 (16.7%) 的患者中,与没有感染 (5.9%) 或晚期感染 (10.7%) 的患者相比,先前的排斥发作更为频繁.
- 与早期感染 (127.5μmol/L) 或没有感染 (113.0μmol/L) 相比,晚期CMV感染的患者 (219.5μmol/L) 的血清肌素水平中位数显著更高,表明功能障碍.
结论:
- 对CMV感染的风险因素因移植后的时间而异.
- 功能障碍成为晚期CMV感染的潜在关键预测因素.
- 识别晚期CMV感染风险的患者对于实施有针对性的监测策略和改善长期移植结果至关重要.
相关概念视频
01:28Kidney Transplant I: Introduction
310
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
310
01:24Chronic Kidney Disease II: Clinical Manifestations
529
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
529
01:16Kidney Transplant III: Nursing Management
294
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
294
01:29Acute Kidney Injury III: Clinical Manifestations
778
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
778
01:26Kidney Transplant II: Surgical Procedure
289
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
289
01:25Chronic Kidney Disease I: Introduction
545
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
545