慢性昼夜失调在小鼠中加速了萨科佩尼亚的进展
Takashi Seya1,2, Nobuya Koike1, Naoki Okubo1,2
1Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Frontiers in physiology
|December 1, 2025
概括
慢性时差加快肌肉损失和肌肉衰弱,表明昼夜不整是萨尔科佩尼亚的危险因素. 这突出了昼夜节律作为预防与年龄有关的肌肉衰退的目标.
科学领域:
- 时间生物学 时间生物学
- 肌肉生理学 肌肉生理学
- 衰老研究研究 衰老研究
背景情况:
- 由于生活方式因素导致的循环失调与不良健康结果有关.
- 肌肉力量和质量的丧失,即萨尔科佩尼亚,是一个日益严重的公共卫生问题.
- 昼夜干扰和肉症之间的关系尚不清楚.
研究的目的:
- 为了研究慢性昼夜失调对骨肌肉健康的影响.
- 为了确定慢性时差是否会在小鼠中诱导类似于萨尔科佩尼亚的变化.
主要方法:
- 在64周的时间里,小鼠经历了慢性时差 (ADV组) 或固定光暗周期 (LD组).
- 评估了握力,后肢肌肉重量和肌肉组织学.
- 进行了后肢肌肉的转录组分析.
主要成果:
- 慢性时差明显减少了握力和肌肉重量.
- 组织学和转录学分析显示了sarcopenia的特征,包括TWEAK/Fn14信号激活和肌纤维尺寸的减少.
- 观察到补偿性肌肉再生的证据,但不足以防止缩.
结论:
- 循环节错位是沙科佩尼亚的潜在危险因素.
- 昼夜节律是肌肉健康的关键调节者,是 Sarcopenia 预防策略的目标.
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