肥胖的双重负担:解码新陈代谢和女性生殖内分泌学
Yan Chen1,2,3, Rongyu Wang1,3,4, Nannan Zhang3,5
1Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, China.
Frontiers in physiology
|December 1, 2025
概括
妇女的肥胖症通过影响内分泌激素和下丘脑-垂体-卵巢轴来破坏生殖健康. 针对代谢和内分泌共同调节的干预措施可以改善生殖内分泌功能障碍.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 全球肥胖率的上升带来了重大的健康风险,特别是对女性的生殖内分泌健康.
- 与肥胖相关的脂肪组织功能障碍影响关键的内分泌激素 (胰岛素,瘦素,性激素),破坏女性下丘脑-垂体-卵巢轴.
- 系统性炎症,肠道微生物群和代谢物越来越被认为是将代谢失衡与生殖内分泌功能障碍联系在一起的因素.
研究的目的:
- 审查肥胖和女性生殖内分泌疾病之间的复杂关系.
- 探索肥胖影响下丘脑-垂体-卵巢轴的中心和外围机制.
- 突出潜在的治疗策略,以共同调节途径为目标,以改善结果.
主要方法:
- 这是一篇综述性文章,综合了关于肥胖和女性生殖健康的现有研究.
- 这篇评论考察了代谢因素,内分泌激素,炎症和肠道微生物组的相互作用.
- 它分析了各种肥胖治疗策略及其对生殖内分泌功能的影响.
主要成果:
- 肥胖通过复杂的荷尔蒙和代谢途径显著导致女性的生殖内分泌疾病.
- 下垂体-垂体-卵巢轴的调节失调是肥胖的一个关键后果.
- 包括生活方式改变,药物治疗和手术在内的各种肥胖管理策略,在改善生殖内分泌功能障碍方面表现出有效性.
结论:
- 解决肥胖问题对于减轻女性生殖内分泌功能障碍至关重要.
- 针对涉及代谢和内分泌系统的共同调节机制,提供了有前途的治疗途径.
- 临床医生应优先考虑对肥胖对女性生殖健康的影响的认识和干预策略.
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