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Updated: Jan 9, 2026

Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.
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在具有TNNT2sarcomeric变体的hiPSC衍生心肌细胞中,表型特异性的核膜重塑

Isabella Leite Coscarella1,2, Olalekan H Usman1, Lili Wang3

  • 1Biomedical Sciences, Florida State University, Tallahassee, FL, USA.

iScience
|December 1, 2025
PubMed
概括

心脏收缩率的变化会影响心肌病中的核力学. 减弱的收缩性会改变核度,但肌调节器可以恢复它,揭示新的治疗点.

关键词:
生物科学 生物科学细胞生物学 细胞生物学自然科学 自然科学干细胞研究的研究.

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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