相关实验视频

Updated: Jan 9, 2026

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

辐射诱发的淋巴缺血症:数据汇编,揭示相关因素和缓解策略

Vladislav Sandul^1,2, Sarah Salih Al-Hamami^3,4, Jiří Kubeš³

¹Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany.

Clinical and translational radiation oncology

|December 1, 2025

概括

放射治疗 (RT) 导致辐射诱导的淋巴缺血 (RIL),影响抗瘤免疫力. 这项研究量化了RIL,揭示了粒子疗法比光子疗法更好地节省淋巴细胞.

科学领域:

辐射瘤学辐射瘤学
免疫学免疫学免疫学
医学物理医学物理

背景情况:

辐射诱导的淋巴缺血症 (RIL) 是放射治疗 (RT) 的常见并发症.
RIL可能会对抗瘤免疫力和免疫疗法的有效性产生负面影响.
人们对RIL的机制和决定因素还不太了解.

研究的目的:

量化分析RT期间和之后的绝对淋巴细胞计数 (ALC) 动态.
为了确定严重淋巴缺血症的关键预测因素.
了解不同RT方式对淋巴细胞计数的影响.

主要方法:

来自52个出版物的142个ALC曲线的系统编译和定量分析.
将数据集成到一个标准化数据库中,涵盖各种RT模式 (X射线,带电粒子,ECIB).
统计分析以确定淋巴衰竭的预测因子,并比较RT技术.

主要成果:

在RT期间持续的淋巴细胞枯竭,中位数ALC降至基线的24% (体内) 和10% (ECIB).
不完全和取决于癌症类型的恢复,在一年内达到基线中位数的55%.
基线ALC,PTV和剂量参数预测严重的淋巴缺血;颗粒疗法显示,与光子疗法相比,治疗结束时的ALC高11%.

结论:

建立了一个全面的,定量基础,以了解RIL.
ALC数据库有助于机械研究和基于模型的淋巴细胞动态预测.
这些发现指导了淋巴细胞节约RT策略的设计,包括粒子疗法.

关键词:

免疫治疗是一种免疫疗法.淋巴细胞计数淋巴细胞计数微粒疗法是一种微粒疗法.质子疗法是一种质子疗法.辐射诱导的淋巴缺血症.

更多相关视频

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes

An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes

Published on: December 25, 2021

相关概念视频

Biological Effects of Radiation

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...