与SGLT2抑制剂治疗的患者的无痛甲状腺炎相关的糖尿病酸性酸症
Ryoichiro Aotani1, Toshiaki Ohkuma1, Ayaka Oshiro1
1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka Prefecture, Japan.
Case reports in endocrinology
|December 1, 2025
概括
-葡萄糖共运输体2 (SGLT2) 抑制剂可以增加糖尿病酸性脂肪酸症 (DKA) 的风险. 这一案例表明,轻微的甲状腺毒性,结合SGLT2抑制剂的使用,即使在轻微的代谢变化中也可以触发DKA.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- -葡萄糖共运输体2 (SGLT2) 抑制剂可以改善血糖控制,降低2型糖尿病的心血管/风险.
- 由于刺激性脂解,SGLT2抑制剂与糖尿病酸症 (DKA) 的风险增加有关.
- 严重的甲状腺毒性是已知的DKA风险因素,促进脂解和生产.
研究的目的:
- 报告2型糖尿病患者使用SGLT2抑制剂,与无痛甲状腺炎相关的DKA病例.
- 突出SGLT2抑制剂治疗和甲状腺毒性病在导致DKA的潜在相互作用.
主要方法:
- 一个62岁的男性患有2型糖尿病,接受SGLT2抑制剂治疗的病例报告.
- 临床表现,实验室发现和DKA的治疗.
- 在治疗期间和治疗后监测血糖和甲状腺功能参数.
主要成果:
- 患者患上了与无痛甲状腺炎相关的DKA.
- 胰岛素治疗和液体输液使血糖和水平正常化.
- 甲状腺功能在没有特殊治疗的情况下自发正常化,并保持稳定.
结论:
- 甲状腺毒性病可以在服用SGLT2抑制剂的患者中放大DKA风险,即使是轻微的甲状腺功能障碍,由于增强的脂解.
- SGLT2 抑制剂可能会降低 DKA 的值,特别是在血糖控制不良或轻微代谢障碍的患者中.
- 随着SGLT2抑制剂的使用增加,以预防DKA,仔细监测至关重要.
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