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Updated: Jan 9, 2026

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
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Published on: May 12, 2023

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通过5 - FU和G-四重复合联体的协同组合逆转L3介导的化学阻力

Anna Di Porzio1, Annalisa Pecoraro1, Camilla Danisi1

  • 1Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.

NAR cancer
|December 1, 2025
PubMed
概括

这项研究结合了5-fluorouracil (5-FU) 与G-quadruplex (G4) 配体,以克服结直肠癌 (CRC) 中的化学抵抗. 这种新的方法选择性地向瘤细胞,减少5-FU剂量并提高治疗效率.

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