静脉血栓塞栓症的风险与短期暴露于微颗粒物 (PM2.5) 和臭氧空气污染有关
Scott C Woller1,2, Scott M Stevens1,2, Joseph R Bledsoe3,4
1Department of Medicine, Intermountain Medical Center, Intermountain Health, Salt Lake City, Utah, USA.
Research and practice in thrombosis and haemostasis
|December 1, 2025
概括
短期空气污染,包括细颗粒物 (PM2.5) 和臭氧,几乎没有证据表明增加静脉血栓栓塞 (VTE) 风险. 然而,野火季节暴露于臭氧可能会变化地增加VTE风险.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 肺部医学 肺部医学
背景情况:
- 空气污染和心血管疾病之间存在确定的联系,但与静脉血栓塞栓症 (VTE) 的关联仍然不清楚.
- 季节性空气污染变化的影响,如野火和逆转季节,对VTE风险的影响尚不清楚.
研究的目的:
- 调查环境空气污染的短期暴露与发展VTE的风险之间的关联.
- 探索不同季节空气污染相关的VTE风险的潜在差异 (野火与反转).
主要方法:
- 一项回顾性队列研究分析了在综合医疗保健系统中从2008年到2022年的VTE发生情况.
- 空气污染数据,特别是细颗粒物 (PM2.5) 和臭氧,每天被评估,并连续多天评估.
- 对夏季野火季节 (六月至十月) 和冬季逆转季节 (十一月至三月) 的VTE结果进行了检查.
主要成果:
- 在25,083例中,在短期暴露于PM2.5和VTE风险之间没有发现显著的关联.
- 在滞后的2天臭氧暴露和增加的VTE风险 (OR,1.03 per +10 ppb) 之间观察到显著的关联.
- 在野火季节,升高的臭氧与各种滞后时间 (1天,3天和7天平均值) 的VTE几率增加有关.
结论:
- 短期暴露于PM2.5和臭氧表明,对整体增加VTE风险的证据很少.
- 季节性分层表明,特别是在野火季节暴露于臭氧可能与VTE的变化风险有关.
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