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一个被遗忘的边界:脊髓刺激治疗阴性和创伤性外周神经病痛

Linda Kollenburg¹, Hisse Arnts¹, Inge Arnts²

¹Department of Neurosurgery, Radboud University Medical Center, Radboud University, Nijmegen, Netherlands.

Frontiers in pain research (Lausanne, Switzerland)

|December 1, 2025

概括

脊髓刺激 (SCS) 有效地治疗创伤性或阴性外周神经病变 (PN) 的严重疼痛. 这项研究表明,SCS显著减少疼痛,并改善患者满意度,并发症最小.

科学领域:

神经学神经学
疼痛管理疼痛管理
神经外科神经外科

背景情况:

周围神经病变 (PN) 可以导致衰弱的,耐治疗的疼痛,特别是在创伤或阳性损伤后.
传统的治疗方法往往不足以控制严重的PN疼痛.
脊髓刺激 (SCS) 是一种潜在的治疗选择,但对其在这些特定情况下的疗效的研究是有限的.

研究的目的:

评估脊髓刺激 (SCS) 治疗外围神经病变 (PN) 的疗效,患者满意度和安全性,这些病变是由于创伤和/或催化剂引起的.
评估SCS作为治疗不治不治的PN疼痛的治疗方法,对其他疗法没有反应.

主要方法:

从2005年至2021年期间接受SCS的创伤性/阴性PN患者的术后数据的回顾性分析.
通过数值评分表 (NRS) 测量效率,响应者被定义为NRS减少≥50%.
从电子病历中收集的数据,使用描述性统计数据进行分析.

主要成果:

在15名患者中,有63%的患者是响应者,平均NRS降低了63% (从8.1到3.0) (p<0.01).
所有患者都表示对他们的SCS植入物感到满意.
一个单一的并发症 (表面感染) 在6%的患者中发生.

结论:

脊髓刺激 (SCS) 是一个有前途的疗法,可以有效地治疗外伤或阳性因素引起的外周神经病变 (PN).
由于其能够集中准多个神经根,SCS可能比外围神经刺激 (PNS) 和背部根结节刺激 (DRG) 有优势.
需要进一步的前性试验来比较SCS与PNS和DRG刺激,以确定其在难治PN的临床指南中的作用.

关键词:

慢性疼痛是一种慢性疼痛.神经病变性疼痛是一种神经性疼痛.周围神经受伤的情况周围神经病变 (Peripheral Neuropathy) 是一种神经病变.脊髓刺激脊髓刺激

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