免疫检查点抑制剂后结核病感染:一个真实世界的观察性研究
Mei Zhan1,2, Linyan Zhou1,2, Ran Liu3
1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in pharmacology
|December 1, 2025
概括
免疫检查点抑制剂 (ICI) 治疗与1.96%的结核病 (TB) 发病率有关. 以前存在的结核病和男性是ICI治疗后发展结核病的关键风险因素,需要提高临床警.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗.
- 人们越来越担心ICI可能会重新激活或触发诸如结核病 (TB) 等潜在感染.
研究的目的:
- 在接受免疫检查点抑制剂 (ICI) 的患者中确定结核病 (TB) 感染的发生率.
- 在接受ICI治疗的患者中确定与发展结核病相关的风险因素.
主要方法:
- 对8199名患者的回顾性审查,这些患者在2023年6月之前接受了ICI治疗.
- 后勤回归分析以确定与ICI启动后结核病发展相关的临床特征.
主要成果:
- 在ICI开始后结核病的发病率为1.96%.
- 以前存在的结核病 (OR 3.277) 和男性 (OR 1.798) 与增加的结核病风险有显著的关联.
- 肺结核是最常见的表现.
结论:
- 在接受ICI治疗的癌症患者中观察到结核病的显著发病率.
- 由于结核病风险,建议对接受ICI治疗的患者加强临床警.
- 需要进一步的前性研究来量化可归因于ICI的过度结核病风险.
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