多模式核磁共振 (MRI) 显示,COVID-19幸存者的基底和边缘系统发生了一致的变化
Sapna S Mishra1, Caterina A Pedersini2,3, Rohit Misra1
1Department of Electrical Engineering, Indian Institute of Technology Delhi, New Delhi, India.
Imaging neuroscience (Cambridge, Mass.)
|December 1, 2025
概括
幸存者COVID-19显示大脑结构变化,包括缩和稀薄,特别是在严重的情况下. 特定脑道的微观结构损伤与感染严重程度相关,影响认知电路.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- COVID-19对大脑的长期影响,称为后COVID综合征 (PCS),尚未完全理解.
- 在研究中发现的高变异性阻碍了PCS机制的凝聚力理论.
研究的目的:
- 调查COVID-19对大脑结构和功能的多式联络,长期的神经影响.
- 确定与后COVID综合征相关的神经成像生物标志物,并将它们与感染严重程度相关联.
主要方法:
- 多模式MRI分析 (T1-MRI,扩散MRI,功能MRI,ASL-MRI) 在COVID康复患者 (CRPs) 和健康对照 (HCs) 中.
- 横截面研究比较大脑形态,组织微观结构,功能连接和大脑血流.
- 基于感染严重程度的CRP分层 (住院 vs 非住院).
主要成果:
- 在基底和边缘结构中,CRP表现出焦点缩,在准边缘区域出现皮质稀薄.
- 观察到白质完整性降低 (微分异性,辐射扩散性) 在未结合的和环膜.
- 在住院患者中,微观结构损伤更为明显;在严重病例中,观察到休息状态功能连接性 (RSFC) 减弱.
结论:
- COVID-19与基底 - 边缘皮层电路的选择性结构和功能变化有关.
- 感染的严重程度显著影响微观结构损伤的程度和功能连接变化.
- 这些发现验证了现有的,并揭示了后COVID综合征的新型神经成像生物标志物,指导了未来的研究.
关键词:
权重为T1的核磁共振成像动脉旋转标签 (ASL) 是指动脉旋转标签.扩散权重核磁共振成像 (dMRI) 是一种扩散权重核磁共振成像.后COVID综合征 (PCS) 是一种疾病.休息状态的功能性MRI (rs-fMRI)更多相关视频
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