Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
MicroRNAs01:22

MicroRNAs

23.9K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.9K
MicroRNAs01:22

MicroRNAs

3.7K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

De-extinction of the Northern white rhinoceros (Ceratotherium simum cottoni).

The Journal of reproduction and development·2026
Same author

Synaptophysin autoantibodies mediate synaptic dysfunction in cerebellar ataxia.

Cell reports. Medicine·2026
Same author

Alzheimer's disease risk single nucleotide polymorphism rs11218343 is linked to functional expression of SORL1 in microglia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Trem2 exacerbates ischemic brain injury through Gpnmb in a photothrombotic stroke model.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Deep immune-phenotyping of HLA-homozygous iPS-cardiomyocytes by spectral flow cytometry.

Frontiers in immunology·2026
Same author

The functional role of glial cells in the pathologic brain as reviewed by Alois Alzheimer in 1910.

Molecular neurodegeneration·2026
Same journal

Research advances and application prospects of CAR-T therapy in the treatment of age-related diseases.

Frontiers in immunology·2026
Same journal

Machine learning-driven identification and immunohistochemical validation of an integrated immune-inflammatory phenotype for disease-free survival stratification in breast cancer.

Frontiers in immunology·2026
Same journal

Modified treatment protocol for pediatric systemic lupus erythematosus-associated hemophagocytic lymphohistiocytosis with central nervous system involvement: a case report.

Frontiers in immunology·2026
Same journal

Exploratory characterization of IgG1/IgG4 glycosylation and monocyte-derived dendritic cell responses in esophageal squamous cell carcinoma.

Frontiers in immunology·2026
Same journal

JAK-STAT pathway-associated skin diseases: a refined functional framework for inflammatory skin diseases.

Frontiers in immunology·2026
Same journal

Cross-talk among novel programmed cell death pathways: a decisive network in renal ischemia-reperfusion injury.

Frontiers in immunology·2026
查看所有相关文章

相关实验视频

Updated: Jan 9, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.6K

细胞外微RNAs通过TLR8调节人类的微质功能.

Hannah Weidling1,2,3, Edyta Motta1,2, Leonard D Kuhrt2,3,4

  • 1Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Frontiers in immunology
|December 1, 2025
PubMed
概括
此摘要是机器生成的。

中枢神经系统 (CNS) 疾病相关的microRNAs (miRNAs) 通过Toll-like受体8 (TLR8) 发出信号,以调节人类微质功能. 这些miRNAs调节神经炎症和神经细胞外生,为中枢神经系统疾病提供潜在的治疗点.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.细胞外的微RNA.质瘤 质瘤 是一种人类微质细胞这就是 iPSC 的意义.微质的功能 微质的功能干细胞是干细胞的组成部分.收费类受体 8 收费类受体

更多相关视频

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

19.9K
Obtaining Human Microglia from Adult Human Brain Tissue
09:41

Obtaining Human Microglia from Adult Human Brain Tissue

Published on: August 30, 2020

7.7K

相关实验视频

Last Updated: Jan 9, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.6K
Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

19.9K
Obtaining Human Microglia from Adult Human Brain Tissue
09:41

Obtaining Human Microglia from Adult Human Brain Tissue

Published on: August 30, 2020

7.7K

科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学

背景情况:

  • 微RNAs (miRNAs) 是大脑中的关键基因调节者,调节失调与中枢神经系统 (CNS) 疾病有关.
  • 微RNA可以作为托尔类受体 (TLR) 的配体,影响免疫反应.

研究的目的:

  • 研究中枢神经系统疾病相关的miRNAs作为人类微质细胞的信号分子.
  • 确定托尔类受体 (TLRs) 在调解微质上miRNA效应中的作用.

主要方法:

  • 机器学习识别了阿尔茨海默病 (AD) 和质瘤相关的miRNAs作为TLR7/TLR8连接体.
  • 人类微状细胞 (iMGLs) 用于评估miRNA诱导的细胞因子释放,运动和细胞发生的变化.
  • 用一种选择性TLR8抗剂 (CU-CPT9a) 来确认受体参与.

主要成果:

  • 特定的miRNAs (miR-9-5p,miR-132-5p,等等) 的使用. 被确定为TLR7和TLR8的配体.
  • 暴露于某些miRNAs调节了iMGL细胞因子的产生 (IL-6,TNF),运动性和细胞化.
  • 在共同培养中,TLR8对抗消除了miRNA诱导的微质反应,细胞外miRNA减少了神经元长度.

结论:

  • 与中枢神经系统疾病相关的miRNAs通过TLR8.8作为人类微质的信号分子起作用.
  • 这些miRNAs调节微质功能和神经炎症反应,影响神经细胞外生长.