相关实验视频

Updated: Jan 9, 2026

Murine Fecal Isolation and Microbiota Transplantation

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

老年中国高血压患者的肠道微生物群失调和全身炎症:一个病例控制研究

Yiwen Cheng^1,2, Yihua Huang³, Zhangcheng Zhu⁴

¹State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, China-Singapore Belt and Road Joint Laboratory on Infection Research and Drug Development, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Frontiers in immunology

|December 1, 2025

概括

高血压与肠道细菌失衡和炎症有关. 这项研究确定了与中国老年人高血压相关的特定肠道微生物和炎症标志物,这表明了新的诊断和治疗途径.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
老年学是指老年学的学科.

背景情况:

高血压 (HTN) 是全球主要的健康问题,控制率低,心血管风险很大.
肠道微生物群失生症越来越多地与高血压 (HTN) 病原发生有关,但机制需要进一步阐明.
迫切需要有效,可访问和个性化的HTN管理策略.

研究的目的:

调查中国老年人高血压和没有高血压的肠道微生物群组成和全身炎症.
为了识别与高血压相关的微生物特征和炎症标志物.
探索肠道失调,炎症和高血压之间的关系.

主要方法:

一项涉及205名中国老年人 (153名HTN患者,52名对照) 的病例控制研究.
使用NovaSeq测序分析肠道微生物组成.
通过多重免疫试验评估系统性炎症;用于分析的肠型和ROC建模.

主要成果:

在HTN患者中,肠道微生物群的多样性发生了变化,包括*Escherichia_Shigella*,*Prevotella_9*和*Enterococcus*的丰富,以及*Blautia*和酸盐生产者的枯竭.
在HTN患者中,以*Escherichia_Shigella*为主导的肠型更为普遍.
在HTN患者中观察到高水平的促炎细胞因子 (IL-1ra,TNF-α),与特定的肠道微生物模式相关.

结论:

肠道失调和慢性低度系统性炎症是老年人高血压的关键特征.
特定的肠道细菌 (*Blautia*, *Butyricicoccus*, *Lachnoclostridium*, *Prevotella_9*, *Enterococcus*) 显示出它们可能成为高血压的诊断生物标志物.
这些发现支持开发基于微生物群的高血压诊断和治疗策略.

关键词:

蓝色的蓝色的蓝色进入类型进入类型进入类型肠道失调症是一种肠道失调症.这种高血压,高血压.这是一种炎症炎症炎症炎症.

更多相关视频

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions

Published on: June 6, 2025

相关概念视频

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...