三糖-葡萄糖指数作为心血管多病症的预测指标:一项前性队列研究
Yushi Bao1,2, Hao Chen2, Bolin Zhu3
1Department of Clinical Labortatory, Shanghai Songjiang District Sijing Hospital, Shanghai, China.
Frontiers in cardiovascular medicine
|December 1, 2025
概括
甘油三糖 (TyG) 指数预测心血管多病症 (CVM) 的进展. 较高的TyG指数与心血管疾病 (CVD) 和CVM的发展有关,特别是动脉样硬化驱动的疾病,如冠心病和中风.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 公共卫生 公共卫生
背景情况:
- 甘油三糖指数 (TyG) 是胰岛素耐药性的标志物.
- 它在从心血管疾病 (CVD) 到心血管多病症 (CVM) 的进展中的作用尚不清楚.
研究的目的:
- 调查TyG指数与从无心血管疾病状态过渡到首先心血管疾病,然后到CVM之间的关联.
- 探索TyG指数在疾病特异性心血管路径中的作用.
主要方法:
- 在基线没有心血管疾病的成年人的前性队列研究 (2016年).
- 在基线测量TyG指数;在6.26年内追踪疾病转变.
- 用于分析TyG指数和过渡到CVD和CVM之间的关联的多状态模型.
主要成果:
- 1,182名参与者出现了首次心血管疾病事件,671人出现了CVM.
- TyG指数与第一个CVD和CVM的过渡有关 (HR=1.162,HR=1.148).
- TyG指数显示了与冠状动脉心脏病 (HR=1.145),中风 (HR=1.228) 和心力衰竭 (HR=1.213) 的差异关联.
结论:
- 泰格指数独立预测心血管多病症的进展.
- 它与动脉样硬化驱动的疾病,如冠状动脉疾病和中风有关,但不是心力衰竭.
- TyG指数可能有助于风险分层和预防心血管疾病连续性的预防策略.
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