增强皮肤输送安福特里辛B:开发和评估聚合物纳米颗粒使用猪耳模型
Magno Maciel-Magalhães1,2,3,4, David Emanuel Ybarra4,5, Daniela Maza Vega4,5
1Laboratório de Fisiologia, Instituto Nacional de Controle de Qualidade em Saúde (INCQS), Fundação Oswaldo Cruz (Fiocruz), Av. Brasil, 4365, Rio de Janeiro 21040-900, Brasil.
ACS omega
|December 1, 2025
概括
装有安福特素B (AmB) 的聚合物纳米颗粒显示出治疗真菌感染和莱什曼病的潜力. 这些纳米粒子改善了药物输送,PLA纳米粒子到达表皮,PCL纳米粒子穿透角层.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 氨酸B (AmB) 是一种重要的抗真菌和抗莱什曼药物.
- 它的临床使用受到口服生物利用性差以及显著副作用的阻碍.
- 聚合物纳米粒子 (PNPs) 提供了一个有前途的替代药物输送系统.
研究的目的:
- 开发和描述安福特素B载荷的聚乳酸 (PLA) 和聚烯酸 (PCL) 聚合物纳米粒子.
- 为了评估这些AMB载荷PNP的稳定性和皮肤透性.
- 评估它们在局部治疗真菌感染和皮肤莱什曼病的潜力.
主要方法:
- 纳米沉被用来产生带有AmB的PLA和PCL PNP.
- 描述涉及动态光散射,扫描传输电子显微镜和拉曼光谱学.
- 使用静态多重光散射 (SMLS) 评估稳定性,并在猪皮肤模型中评估皮肤透性.
主要成果:
- 氨基氨酸B载荷的PLA和PCLPNPs已成功合成.
- PLA + AmB PNP 已证明可以透到活性的表皮.
- PCL + AmB PNP显示通过角层的透.
结论:
- 装有安福特里B的PLA和PCLPNP都是局部药物输送的可行候选者.
- 这些PNP显示了对表面真菌感染和皮肤莱什曼病的有效治疗的潜力.
- 聚合物纳米粒子是一个有希望的战略,以克服AMB的交付限制.
相关概念视频
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:15Antifungal Agents
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...