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相关概念视频

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
1.2K
Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle01:19

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

1.6K
Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
1.6K
Mass Spectrometry: Isotope Effect01:13

Mass Spectrometry: Isotope Effect

3.8K
Most elements exist in nature as a mixture of isotopes. The isotopes differ in weight due to their respective number of neutrons. The molecular weight of a molecule is different depending on the specific isotope of its elements involved. As a result, the mass spectrum of the molecule exhibits peaks from the same fragment at multiple positions. The positions of these mass signals depend on the mass differences between isotopes. Furthermore, the intensity of these signals is dependent on the...
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Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation01:26

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

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Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy  (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used....
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Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

2.3K
Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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相关实验视频

Updated: Jan 9, 2026

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
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Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

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诱导合等离子体质谱学的多同位素内部标准化.

Micah X DeCourcey1, Abigail J Crossman1, Willis B Jones1

  • 1Department of Chemistry and Biochemistry, University of North Florida, Jacksonville, Florida 32224, USA.

ACS omega
|December 1, 2025
PubMed
概括

多同位素内部标准化 (MIIS) 是一种用于感应合等离子体质谱 (ICP-MS) 的新校准方法. 这种技术提高了微量分析物确定的准确性和效率,优于传统方法.

科学领域:

  • 分析化学 分析化学
  • 频谱测量是一种光谱测量.

背景情况:

  • 传统的微量分析剂确定依赖于单个信号与度关系.
  • 现有的多信号方法面临着诸如低吞吐量,复杂矩阵的准确性差以及对每个分析物的多个信号的要求等局限性.

研究的目的:

  • 引入和评估多同位素内部标准化 (MIIS) 作为ICP-MS的先进校准方法.
  • 解决现有的多信号技术在微量分析物确定中的局限性.

主要方法:

  • 开发了一种新的校准方法,MIIS,利用多个同位素质量进行分析和内部标准.
  • 仅使用两个校准解决方案来构建校准曲线.
  • 通过复杂矩阵的尖峰回收实验和对认证参考材料的分析验证MIIS.

主要成果:

  • 在具有挑战性的样本矩阵中,MIIS在较低的相对标准偏差 (几个百分比) 中实现了大约100%的分析物回收.
  • 与传统校准和其他多信号方法相比,表现出优越的性能.
  • 在经过认证的参考材料中进行的验证显示,恢复率在85%至111%之间.

结论:

  • MIIS在ICP-MS校准中提供了显著的进步,用于痕迹分析剂的确定.

更多相关视频

A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS
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Automated Sample Multiplexing by using Combined Precursor Isotopic Labeling and Isobaric Tagging cPILOT
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Automated Sample Multiplexing by using Combined Precursor Isotopic Labeling and Isobaric Tagging cPILOT

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相关实验视频

Last Updated: Jan 9, 2026

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A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS
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A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS

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Automated Sample Multiplexing by using Combined Precursor Isotopic Labeling and Isobaric Tagging cPILOT
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  • 该方法提供了大量的校准点,而溶液的制备量最小.
  • MIIS克服了以前技术的局限性,提高了准确性和效率.