结构和磁性表征,生物医学应用,和高精度的相互作用的四度纳米螺旋铁
Suhailah S Aljameel1,2, Abdulhadi Baykal3,4, Munirah Abdullah Almessiere5,6
1Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
ACS omega
|December 1, 2025
概括
这项研究合成了纳米螺旋铁酸盐 (NSFs) 与不同的子,揭示了可调节的磁性特性和显著的抗癌和抗微生物活性. CoNiZnCu的NSF显示出对乳腺癌细胞的抗癌效果最高.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 固态化学 固态化学
背景情况:
- 螺旋铁是多功能磁性材料,在各种技术中具有应用.
- 定制纳米螺旋铁 (NSF) 中的阴离子组成对于优化它们的磁性和功能性质至关重要.
- 了解兴奋剂和温度对磁性排序的影响对于材料设计至关重要.
研究的目的:
- 为了合成和表征五种不同的纳米螺旋铁酸盐 (NSFs),具有不同的Co,Ni,Mn,Zn和Cu组成.
- 为了研究这些NSF在室温和10K的磁性特性.
- 评估这些NSF的潜在生物医学应用,包括抗癌和抗菌活动.
主要方法:
- 索尔凝自动燃烧路径用于合成NSFs.
- 用X射线衍射 (XRD) 和能量散射X射线 (EDX) 光谱进行结构和组成分析.
- 莫斯巴乌尔光谱法用于确定阴子分布和电子性质.
- 振动样品磁力计 (VSM) 用于测量300K和10K的磁性参数 (Ms,Mr,Hc).
- MTT测定和DAPI染色用于评估对MCF-7和HEK-293细胞的细胞毒性.
- 汁稀释方法用于评估对Enterococcus faecalis和Candida albicans的抗菌活性.
主要成果:
- 证实了具有15-26nm之间的晶体体尺寸的立方晶体纳米产品.
- 发现Zn2+离子占据了A位点,增加了Fe3+离子的s电子密度.
- CoNiMnCu NSF表现出高磁硬度和异构性,而NiMnZnCu NSF表现出柔软的磁性行为.
- 所有样本在10K时都观察到磁性排序和异性质的显著增强.
- CoNiZnCu NSFs对MCF-7细胞 (57.95%活力) 和诱导的亡表现出最高的抗癌活性.
- NSFs显示对癌细胞的选择性细胞毒性超过正常细胞.
- 大多数NSF对E. faecalis表现出强烈的抗菌活性,CoMnZnCuNSF对C. albicans表现出显著的抗真菌活性.
结论:
- 阴子工程和温度显著影响纳米螺旋铁的磁性.
- 合成的NSF具有可调节的磁性特性,可用于永久磁铁,传感器和磁性设备中的应用.
- 由于其强大的抗癌和选择性细胞毒性作用,CoNiZnCuNSF对生物医学应用具有显著的潜力.
- NSF 证明了选择性的抗微生物疗效,这表明开发新型抗微生物剂的潜力.
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