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用伦瓦提尼布治疗转移性恶性卵巢瘤的长期疾病控制:一个病例报告
Ryota Kawano1, Tomoko Sumikura2, Kohki Shimazu3
1Otolaryngology - Head and Neck Surgery, Osaka General Medical Center, Osaka, JPN.
Cureus
|December 1, 2025
概括
恶性卵巢瘤,一种罕见的卵巢瘤,可长期使用伦瓦替尼 (LVB) 治疗转移性疾病. 这种疗法显示出持续瘤控制的潜力,即使有剂量调整和中断.
科学领域:
- 妇科瘤学 妇科瘤学
- 内分泌学 在内分泌学.
- 医学瘤学 医学瘤学
背景情况:
- 卵巢 (Struma ovarii) 是一种罕见的单皮性瘤,主要由甲状腺组织组成.
- 虽然通常是良性的,但可能发生恶性转变,呈现出局部入侵或转移.
- 恶性卵巢瘤经常模仿差分化甲状腺癌.
研究的目的:
- 报告患有转移性疾病的恶性卵巢瘤病例.
- 评估伦瓦提尼布 (LVB) 治疗的疗效和长期管理.
- 探索血清甲状腺蛋白 (Tg) 作为疾病活性生物标志物的作用.
主要方法:
- 一个被诊断患有恶性卵巢瘤的患者的病例报告.
- 基因组分析揭示了NRAS突变.
- 用伦瓦提尼布 (LVB) 治疗转移性疾病,包括剂量修改和中断.
- 血清甲状腺蛋白 (Tg) 水平的监测和疾病进展的成像.
主要成果:
- 伦瓦丁尼布 (LVB) 诱导了肝脏和骨盆转移的显著回归.
- 剂量减少和治疗中断与Tg水平增加和疾病进展有关.
- 通过降低剂量的LVB和计划的药物假期实现了疾病稳定,从而允许长期存活.
- 患者在复发后存活了7年,其中6年接受了LVB治疗.
结论:
- 恶性卵巢瘤可以通过长期的伦瓦提尼布 (LVB) 治疗来有效管理.
- 血清甲状腺蛋白 (Tg) 水平与疾病活性和治疗反应相关.
- 伦瓦丁尼布 (LVB) 为晚期恶性卵巢瘤提供了潜在的治疗选择,证明了持续的瘤控制.
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