25-基维生素D水平与喉癌风险之间的因果关系:一个双样本的门德尔随机化研究
Dapeng Wang1, Li Zhang2, Yanfen Cui3
1Department of Radiation Oncology, Shanxi Medical University/Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, P.R. China.
Food & nutrition research
|December 1, 2025
概括
较高的25-氧维生素D (25(OH) D水平可能会降低喉癌 (LC) 的风险. 这项孟德尔随机化研究表明,维生素D对LC发育具有保护作用.
科学领域:
- 营养流行病学 营养流行病学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 25维生素D (25维生素D) 与喉癌 (LC) 风险之间的关联仍然不完全理解.
- 调查这种关系对于针对LC的潜在预防策略至关重要.
研究的目的:
- 确定25~OH) D水平与患喉癌的风险之间的潜在因果关系.
- 使用两个样本的门德尔随机化 (MR) 方法来评估这种关联.
主要方法:
- 采用了两个样本的门德尔随机化 (MR) 分析.
- 使用的单核酸多态 (SNPs) 与大规模的全基因组关联研究 (GWAS) 中的25(OH) D水平和LC风险相关.
- 应用了多种MR方法,包括MR-Egger,加权中位数和反变量加权 (IVW) 分析.
主要成果:
- 无变MR表明,基因预测较高的25(OH) D水平与降低的LC几率有关 (IVW:OR=0.9993,P=0.019).
- 在调整吸烟和饮酒后,多变量MR还表明,较高的25(OH) D对LC风险具有保护作用 (IVW:OR=0.9993,P=0.006到0.011).
- 当仅针对酒精消费量进行调整时,这种关联并不显著 (IVW:OR=0.9995,P=0.077).
结论:
- 门德尔的随机化分析支持高25-氧维生素D水平对喉癌风险的轻微保护作用.
- 研究结果表明,维生素D可能在喉癌的病因学中起作用,因此需要进一步调查.
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