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通过神经骨代谢合来调节3D打印的脚手架,促进骨单元再生

Pengrui Zhang¹, Linfeng Li¹, Caiping Yan¹

¹Department of Orthopedics, Laboratory of Biological Tissue Engineering and Digital Medicine, Institute of Nanomedicine Innovation and Translational Research, Affiliated Hospital of North Sichuan Medical College, No. 1 The South of Maoyuan Road, Nanchong, Sichuan, 637000, PR China.

Bioactive materials

|December 1, 2025

概括

这项研究开发了一个3D打印的水凝支架,通过合神经和骨代谢来增强骨再生. 创新的脚手架成功地恢复了骨单元.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
组织工程是组织工程.

背景情况:

骨单元 (BU) 集成了神经网络,骨组织和血管,通过神经骨代谢合进行再生.
神经骨代谢合恒温的损伤阻碍了有效的BU再生.
目前的策略缺乏改造骨修复这一关键合的方法.

研究的目的:

为了构建一个3D打印的生物模拟水凝支架 (GGMN-GSE) 协同神经骨代谢合.
通过重建电生理微环境和招募功能细胞来恢复骨单元再生.
研究神经骨代谢合促进BU再生的机制.

主要方法:

使用GelMA,MXene,NGF和双向的双层3D打印水凝支架 (GGMN-GSE) 的制造.
GGMN层:内置导电性MXene和用于神经引导和电生理学仿真的微.
GSE层:招募的骨髓衍生干细胞 (BMSCs) 和内皮原生细胞 (EPCs),用于血管和骨再生.

主要成果:

在体外:GGMN-GSE促进了神经纤维再生,神经分泌 (CGRP,GHRH,VIP) 和BMSC受体激活,通过PI3K-Akt/STAT5通路驱动BU再生.
在体内:观察到CGRP+神经 (2.9倍),CD31+血管 (1.8倍) 和新遗传骨基质 (3.6倍) 的显著增加.
CT分析显示,骨体积/总体积 (BV/TV) 达到了97.1%,神经网络,血管和骨组织的3D协同定位.

结论:

GGMN-GSE支架有效地重塑神经骨代谢合的平衡.
这种仿生脚手架促进了协同作用的多规模骨单元再生.
通过恢复神经骨代谢平衡,GGMN-GSE显示出治疗关键骨缺陷的潜力.

关键词:

骨单位骨单位骨单位关键骨缺陷关键骨缺陷关键骨缺陷电子生理学微环境的微环境.神经骨代谢合神经骨代谢合

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