患有COVID-19后疾病的患者的大脑MRI发现:全国性队列研究中的频率和纵向变化
Liv Lygre Furevik1,2, Oksana Lapina1, Elisabeth Stokke Lindland2,3
1Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Frontiers in neurology
|December 1, 2025
概括
在COVID-19后的神经症状中,大脑MRI显示不经常发生变化,对比度增强检测长期炎症. 重复成像提供有限的好处,除非出现新的症状.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- 在COVID-19后持续的神经症状是常见的.
- 在这个人群中,对大脑MRI发现的纵向研究有限.
- 与对比度增强的MRI数据特别稀缺.
研究的目的:
- 为了研究大脑MRI发现的频率和纵向变化.
- 为了评估COVID-19后病情和神经症状的患者.
- 为了评估对比度增强序列的实用性.
主要方法:
- 140名成年患者的前性多中心研究.
- 感染后6个月和12个月的大脑MRI.
- 评估白质的超强度,微型血液和对比度增强.
主要成果:
- 白质超强度和微型血液与对照组相似.
- 在6个月后,4%的患者有炎症/脱叶林化病变.
- 神经增强 (7%) 持续长达12个月,主要是眼运动神经.
结论:
- 大脑MRI主要用于排除COVID-19后的诊断条件.
- 重复的MRI在没有新的症状的情况下具有有限的临床益处.
- 增强对比度的MRI有助于检测长期的炎症过程.
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